Sorafenib
High-quality Bahan Kimia Organik supplied by Jinan Shenghe Chemical Co., Ltd. Competitive pricing, reliable delivery, and full technical support for B2B buyers worldwide.
Specifications
| Molecular Formula | C28H24ClF3N4O6S |
|---|---|
| Molecular Weight | 637.0266 |
| Boiling Point | 523.3°C at 760 mmHg |
| Flash Point | 270.3°C |
| Vapor Pressure | 4.76E-11mmHg at 25°C |
Detailed Chemical Properties & Synonyms
Direct from the manufacturer. Jinan Shenghe Chemical Co., Ltd. supplies this product under ISO-controlled quality with full COA / MSDS / TDS documentation and flexible OEM packaging for global B2B buyers.
Sorafenib · CAS 284461-73-0 · dipasok oleh Jinan Shenghe Chemical Co., Ltd.
Deskripsi
Sorafenib · CAS 284461-73-0 · C21H16ClF3N4O3. UNII 9ZOQ3TZI87. Titik Leleh: 187-226; Titik Leleh: 205.6 °C; Kelarutan: < 0.01 g/L.
Identifikasi
| Nomor Registrasi CAS | 284461-73-0 |
|---|---|
| PubChem CID | 216239 |
| Rumus molekul | C21H16ClF3N4O3 |
| Nama IUPAC | 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide |
| UNII (FDA) | 9ZOQ3TZI87 |
Deskriptor Terhitung
| Berat Molekul | 464.8 |
|---|---|
| XLogP3 | 4.1 |
| Jumlah Donor Ikatan Hidrogen | 3 |
| Jumlah Akseptor Ikatan Hidrogen | 7 |
| Jumlah Ikatan yang Dapat Berputar | 5 |
| Massa Eksak | 464.0863026 |
| Massa Monoisotopik | 464.0863026 |
| Luas Permukaan Polar Topologi | 92.4 |
| Jumlah Atom Berat | 32 |
| Muatan Formal | 0 |
Sifat Fisika & Kimia
| Titik Leleh | 187-226 |
|---|---|
| Titik Leleh | 205.6 °C |
| Kelarutan | < 0.01 g/L |
| Kelarutan | 1.71e-03 g/L |
| LogP | 3.8 |
Deskripsi fisik & catatan penanganan
- Solid
- White solid
- Stable if stored as directed; avoid strong oxidizing agents. /Sorafenib tosylate/
- Produk penguraian yang berbahaya: penguraian termal dapat menghasilkan gas beracun seperti karbon monoksida, karbon dioksida, dan nitrogen oksida. /Sorafenib tosilat/
- Padatan berwarna putih sampai kekuningan atau kecoklatan. Praktis tidak larut dalam media berair, sedikit larut dalam etanol dan larut dalam PEG 400 /Sorafenib tosylate/
- Oral: Tablet, dilapisi film: 200 mg (sorafenib) Nexavar (Bayer, dipasarkan bersama oleh Onyx). /Sorafenib tosilat/
Klasifikasi Bahaya GHS
| Pernyataan bahaya yang dilaporkan | H351 (40%), H360 (40%), H361 (40%), H362 (60%), H372 (60%), H400 (40%), H402 (20%), H410 (60%) |
|---|
H351 (40%): Suspected of causing cancer [Peringatan Carcinogenicity]
H360 (40%): May damage fertility or the unborn child [Bahaya Reproductive toxicity]
Penggunaan yang Terdokumentasi
- Antineoplastic Agents; Protein Kinase Inhibitors
- THERAPEUTIC CATEGORY: Antineoplastic
- Use (kg; approx.) in Germany (2009): >250
- Use (kg; exact) in Germany (2009): 454
- Consumption (g per capita; approx.) in Germany (2009): 0.00305
- Consumption (g per capita; exact) in Germany (2009): 0.00554
Sinonim
Sorafenib; 284461-73-0; BAY 43-9006; sorafenibum; 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide; 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide; 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-2-pyridinecarboxamide; DTXSID7041128; BAY-43-9006; N-(4-Chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcarbamoyl)-4-pyridyloxy)phenyl)urea; 9ZOQ3TZI87; 4-(4-((((4-Chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-N-methyl-2-pyridinecarboxamide; BAY 439006; BAY-439006; CHEBI:50924; L01XE05
Pertanyaan yang Sering Diajukan
Apa nomor CAS dan rumus molekul dari Sorafenib?
CAS 284461-73-0; rumus molekul C21H16ClF3N4O3; berat molekul — g/mol.
Dengan nama lain apa Sorafenib dikenal?
Sorafenib, 284461-73-0, BAY 43-9006, sorafenibum, 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide, 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide.
Apakah Sorafenib diklasifikasikan sebagai berbahaya?
Pernyataan bahaya yang dilaporkan: H351, H360, H361, H362, H372.
Apa sifat fisik utama dari Sorafenib?
Titik Leleh: 187-226; Titik Leleh: 205.6 °C; Kelarutan: < 0.01 g/L; Kelarutan: 1.71e-03 g/L.
Data pada halaman ini diambil dari PubChem (US National Library of Medicine) dan Wikidata. Data spesifik per grade — kadar, kelembapan, ukuran partikel, kemasan, masa simpan — diterbitkan per batch pada COA dan tidak dipublikasikan di sini.
Aplikasi dan bidang penggunaan
Aplikasi tipikal Sorafenib (CAS 284461-73-0; rumus C21H16ClF3N4O3; 464.8 g/mol) mencakup sintesis kimia, bahan kimia halus, dan proses industri terkait. Tim penjualan kami siap menjawab pertanyaan mengenai spesifikasi, COA, dan jumlah besar Sorafenib.
Produk serupa dalam kategori yang sama
Packaging & Shipping
- Standard: 25 kg fiber drum / 200 kg steel drum with double PE liner
- Small pack: 1 kg / 5 kg aluminum foil bag for lab & sample
- Custom: packaging size and labeling per customer requirement
- Lead time: in-stock items ship within 3-5 business days
- Documents: COA, MSDS / SDS, TDS provided with every shipment
- Global: air, sea (FCL / LCL) and express to 80+ countries
Storage & Handling
Store in a cool, dry, well-ventilated place away from heat, direct sunlight and incompatible materials. Keep container tightly closed. Use appropriate personal protective equipment and refer to the SDS for full safety guidance before handling.
Frequently Asked Questions
Yes. A batch-specific COA and free or charged sample are available on request before bulk ordering.
Yes. We offer custom grade, particle size and purity adjustment based on your application and order volume.
MOQ depends on the product; small quantities are supported for R&D and trial runs.
Every batch is tested in-house and retains full traceability from raw material to finished goods.
Why Choose Jinan Shenghe Chemical
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About Jinan Shenghe Chemical Co., Ltd.
Jinan Shenghe Chemical Co., Ltd.
We are a professional chemical supplier based in Jinan, China. Since 2013, we have been connecting manufacturers and global B2B buyers with reliable sourcing, quality-controlled products and efficient logistics.
Our business covers food & feed additives, fine chemicals, pharmaceutical intermediates, eco-materials, coatings and specialty chemicals — all non-hazardous and compliant with our licensed scope.